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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature PG Arnison, MJ Bibb, G Bierbaum, AA Bowers, TS Bugni, G Bulaj, ... Natural product reports 30 (1), 108-160, 2013 | 2133 | 2013 |
Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms MR Rondon, PR August, AD Bettermann, SF Brady, TH Grossman, ... Applied and environmental microbiology 66 (6), 2541-2547, 2000 | 1757 | 2000 |
Lessons from natural molecules J Clardy, C Walsh Nature 432 (7019), 829-837, 2004 | 1598 | 2004 |
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin GD Van Duyne, RF Standaert, PA Karplus, SL Schreiber, J Clardy Journal of molecular biology 229 (1), 105-124, 1993 | 1462 | 1993 |
Structure of the FKBP12-rapamycin complex interacting with binding domain of human FRAP J Choi, J Chen, SL Schreiber, J Clardy Science 273 (5272), 239-242, 1996 | 1152 | 1996 |
D-amino acids trigger biofilm disassembly I Kolodkin-Gal, D Romero, S Cao, J Clardy, R Kolter, R Losick Science 328 (5978), 627-629, 2010 | 1066 | 2010 |
Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria K Tachibana, PJ Scheuer, Y Tsukitani, H Kikuchi, D Van Engen, J Clardy, ... Journal of the American Chemical Society 103 (9), 2469-2471, 1981 | 1058 | 1981 |
Isolation and structure of bryostatin 1 GR Pettit, CL Herald, DL Doubek, DL Herald, E Arnold, J Clardy Journal of the American Chemical Society 104 (24), 6846-6848, 1982 | 1015 | 1982 |
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters P Cimermancic, MH Medema, J Claesen, K Kurita, LCW Brown, ... Cell 158 (2), 412-421, 2014 | 1003 | 2014 |
Target identification using drug affinity responsive target stability (DARTS) B Lomenick, R Hao, N Jonai, RM Chin, M Aghajan, S Warburton, J Wang, ... Proceedings of the National Academy of Sciences 106 (51), 21984-21989, 2009 | 970 | 2009 |
Minimum information about a biosynthetic gene cluster MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ... Nature chemical biology 11 (9), 625-631, 2015 | 907 | 2015 |
GABA-modulating bacteria of the human gut microbiota P Strandwitz, KH Kim, D Terekhova, JK Liu, A Sharma, J Levering, ... Nature microbiology 4 (3), 396-403, 2019 | 904 | 2019 |
Diarrhetic shellfish toxins T Yasumoto, M Murata, Y Oshima, M Sano, GK Matsumoto, J Clardy Tetrahedron 41 (6), 1019-1025, 1985 | 876 | 1985 |
New antibiotics from bacterial natural products J Clardy, MA Fischbach, CT Walsh Nature biotechnology 24 (12), 1541-1550, 2006 | 798 | 2006 |
Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex GD Van Duyne, RF Standaert, PA Karplus, SL Schreiber, J Clardy Science 252 (5007), 839-842, 1991 | 787 | 1991 |
Isolation and structure of brevetoxin B from the" red tide" dinoflagellate Ptychodiscus brevis (Gymnodinium breve) YY Lin, M Risk, SM Ray, D Van Engen, J Clardy, J Golik, JC James, ... Journal of the American Chemical Society 103 (22), 6773-6775, 1981 | 732 | 1981 |
Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA DE Gillespie, SF Brady, AD Bettermann, NP Cianciotto, MR Liles, ... Applied and environmental microbiology 68 (9), 4301-4306, 2002 | 723 | 2002 |
A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics MS Donia, P Cimermancic, CJ Schulze, LCW Brown, J Martin, M Mitreva, ... Cell 158 (6), 1402-1414, 2014 | 706 | 2014 |
D-amino acids govern stationary phase cell wall remodeling in bacteria H Lam, DC Oh, F Cava, CN Takacs, J Clardy, MA de Pedro, MK Waldor Science 325 (5947), 1552-1555, 2009 | 695 | 2009 |