| cGAS surveillance of micronuclei links genome instability to innate immunity KJ Mackenzie, P Carroll, CA Martin, O Murina, A Fluteau, DJ Simpson, ... Nature 548 (7668), 461-465, 2017 | 1560 | 2017 |
| Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development MAM Reijns, B Rabe, RE Rigby, P Mill, KR Astell, LA Lettice, S Boyle, ... Cell 149 (5), 1008-1022, 2012 | 530 | 2012 |
| CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions M Zimmermann, O Murina, MAM Reijns, A Agathanggelou, R Challis, ... Nature 559 (7713), 285-289, 2018 | 380 | 2018 |
| A role for Q/N-rich aggregation-prone regions in P-body localization MAM Reijns, RD Alexander, MP Spiller, JD Beggs Journal of cell science 121 (15), 2463-2472, 2008 | 263 | 2008 |
| Lagging-strand replication shapes the mutational landscape of the genome MAM Reijns, H Kemp, J Ding, SM de Procé, AP Jackson, MS Taylor Nature 518 (7540), 502-506, 2015 | 261 | 2015 |
| Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response KJ Mackenzie, P Carroll, L Lettice, Ž Tarnauskaitė, K Reddy, F Dix, ... The EMBO journal 35 (8), 831-844, 2016 | 253 | 2016 |
| Defective removal of ribonucleotides from DNA promotes systemic autoimmunity C Günther, B Kind, MAM Reijns, N Berndt, M Martinez-Bueno, C Wolf, ... The Journal of clinical investigation 125 (1), 413-424, 2015 | 227 | 2015 |
| Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair MM Ghodgaonkar, F Lazzaro, M Olivera-Pimentel, M Artola-Borán, ... Molecular cell 50 (3), 323-332, 2013 | 206 | 2013 |
| Identification of VP19 and VP15 of white spot syndrome virus (WSSV) and glycosylation status of the WSSV major structural proteins MCW van Hulten, M Reijns, AMG Vermeesch, F Zandbergen, JM Vlak Journal of general virology 83 (1), 257-265, 2002 | 179 | 2002 |
| RNA: DNA hybrids are a novel molecular pattern sensed by TLR9 RE Rigby, LM Webb, KJ Mackenzie, Y Li, A Leitch, MAM Reijns, ... The EMBO journal 33 (6), 542-558, 2014 | 173 | 2014 |
| PCNA directs type 2 RNase H activity on DNA replication and repair substrates D Bubeck, MAM Reijns, SC Graham, KR Astell, EY Jones, AP Jackson Nucleic acids research 39 (9), 3652-3666, 2011 | 159 | 2011 |
| Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions P Heyn, CV Logan, A Fluteau, RC Challis, T Auchynnikava, CA Martin, ... Nature genetics 51 (1), 96-105, 2019 | 158 | 2019 |
| cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing C Uggenti, A Lepelley, M Depp, AP Badrock, MP Rodero, MT El-Daher, ... Nature Genetics 52 (12), 1364-1372, 2020 | 150 | 2020 |
| Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis P Mill, PJ Lockhart, E Fitzpatrick, HS Mountford, EA Hall, MAM Reijns, ... The American Journal of Human Genetics 88 (4), 508-515, 2011 | 149 | 2011 |
| The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease MAM Reijns, D Bubeck, LCD Gibson, SC Graham, GS Baillie, EY Jones, ... Journal of Biological Chemistry 286 (12), 10530-10539, 2011 | 120 | 2011 |
| Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism JJ Reynolds, LS Bicknell, P Carroll, MR Higgs, R Shaheen, JE Murray, ... Nature Genetics 49 (4), 537-549, 2017 | 104 | 2017 |
| TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ME Harley, O Murina, A Leitch, MR Higgs, LS Bicknell, G Yigit, ... Nature genetics 48 (1), 36-43, 2016 | 99 | 2016 |
| DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency CV Logan, JE Murray, DA Parry, A Robertson, R Bellelli, Ž Tarnauskaitė, ... The American Journal of Human Genetics 103 (6), 1038-1044, 2018 | 89 | 2018 |
| RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition M Benitez‐Guijarro, C Lopez‐Ruiz, Ž Tarnauskaitė, O Murina, ... The EMBO journal 37 (15), e98506, 2018 | 82 | 2018 |
| DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes AMS Giordano, M Luciani, F Gatto, M Abou Alezz, C Beghè, L Della Volpe, ... Journal of Experimental Medicine 219 (4), e20211121, 2022 | 64 | 2022 |
Andrew P. JacksonUniversity of EdinburghVerified email at igmm.ed.ac.uk
