Nonviral gene therapy: the promise of genes as pharmaceutical products FD Ledley Human gene therapy 6 (9), 1129-1144, 1995 | 753 | 1995 |
Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. KP Ponder, S Gupta, F Leland, G Darlington, M Finegold, J DeMayo, ... Proceedings of the National Academy of Sciences 88 (4), 1217-1221, 1991 | 444 | 1991 |
Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase SCM Kwok, FD Ledley, AG DiLella, KJH Robson, SLC Woo Biochemistry 24 (3), 556-561, 1985 | 374 | 1985 |
Pharmaceutical approach to somatic gene therapy FD Ledley Pharmaceutical research 13, 1595-1614, 1996 | 319 | 1996 |
Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors. BR Mullin, PH Fishman, G Lee, SM Aloj, FD Ledley, RJ Winand, LD Kohn, ... Proceedings of the National Academy of Sciences 73 (3), 842-846, 1976 | 295 | 1976 |
Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases. HE Grenett, FD Ledley, LL Reed, SL Woo Proceedings of the National Academy of Sciences 84 (16), 5530-5534, 1987 | 277 | 1987 |
Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene AG DiLella, SCM Kwok, FD Ledley, J Marvit, SLC Woo Biochemistry 25 (4), 743-749, 1986 | 277 | 1986 |
The mouse c-abl locus: molecular cloning and characterization JYJ Wang, F Ledley, S Goff, R Lee, Y Groner, D Baltimore Cell 36 (2), 349-356, 1984 | 249 | 1984 |
Contribution of NIH funding to new drug approvals 2010–2016 E Galkina Cleary, JM Beierlein, NS Khanuja, LM McNamee, FD Ledley Proceedings of the National Academy of Sciences 115 (10), 2329-2334, 2018 | 238 | 2018 |
In Vivo Gene Transfer into Rabbit Thyroid Follicular Cells by Direct DNA Injection ML Sikes, BW O'Malley Jr, MJ Finegold, FD Ledley Human Gene Therapy 5 (7), 837-844, 1994 | 198 | 1994 |
Profitability of large pharmaceutical companies compared with other large public companies FD Ledley, SS McCoy, G Vaughan, EG Cleary Jama 323 (9), 834-843, 2020 | 179 | 2020 |
Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II M Hinds, K Deisseroth, J Mayes, E Altschuler, R Jansen, FD Ledley, ... Cancer research 51 (17), 4729-4731, 1991 | 179 | 1991 |
Extensive restriction site polymorphism at the human phenylalanine hydroxylase locus and application in prenatal diagnosis of phenylketonuria. AS Lidsky, FD Ledley, AG DiLella, SC Kwok, SP Daiger, KJ Robson, ... American journal of human genetics 37 (4), 619, 1985 | 165 | 1985 |
Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction R Jansen, F Kalousek, WA Fenton, LE Rosenberg, FD Ledley Genomics 4 (2), 198-205, 1989 | 164 | 1989 |
Why pharmacogenomics? Why now? D Housman, FD Ledley Nature biotechnology 16 (2), 2-3, 1998 | 162 | 1998 |
Non-viral gene therapy FD Ledley Current Opinion in Biotechnology 5 (6), 626-636, 1994 | 156 | 1994 |
Gene transfer and expression of human phenylalanine hydroxylase FD Ledley, HE Grenett, AG DiLella, SCM Kwok, SLC Woo Science 228 (4695), 77-79, 1985 | 152 | 1985 |
Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains FD Ledley, AG DiLella, SCM Kwok, SLC Woo Biochemistry 24 (14), 3389-3394, 1985 | 151 | 1985 |
Overexpression of Human Methylmalonyl CoA Mutase in Mice after In Vivo Gene Transfer with Asialoglycoprotein/Polylysine/DNA Complexes J Stankovics, AM Crane, E Andrews, CH Wu, GY Wu, FD Ledley Human gene therapy 5 (9), 1095-1104, 1994 | 141 | 1994 |
Somatic gene therapy to cells associated with fluid spaces FD Ledley, BW O'Malley Jr US Patent 5,770,580, 1998 | 140 | 1998 |