The disease-associated r (GGGGCC) n repeat from the C9orf72 gene forms tract length-dependent uni-and multimolecular RNA G-quadruplex structures K Reddy, B Zamiri, SYR Stanley, RB Macgregor, CE Pearson Journal of Biological Chemistry 288 (14), 9860-9866, 2013 | 402 | 2013 |
Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response KJ Mackenzie, P Carroll, L Lettice, Ž Tarnauskaitė, K Reddy, F Dix, ... The EMBO journal 35 (8), 831-844, 2016 | 254 | 2016 |
TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r (GGGGCC) n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins B Zamiri, K Reddy, RB Macgregor, CE Pearson Journal of Biological Chemistry 289 (8), 4653-4659, 2014 | 249 | 2014 |
Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats K Reddy, M Tam, RP Bowater, M Barber, M Tomlinson, K Nichol Edamura, ... Nucleic acids research 39 (5), 1749-1762, 2011 | 176 | 2011 |
Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability K Reddy, MHM Schmidt, JM Geist, NP Thakkar, GB Panigrahi, YH Wang, ... Nucleic acids research 42 (16), 10473-10487, 2014 | 123 | 2014 |
TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ME Harley, O Murina, A Leitch, MR Higgs, LS Bicknell, G Yigit, ... Nature genetics 48 (1), 36-43, 2016 | 100 | 2016 |
Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model CF Moss, I Dalla Rosa, LE Hunt, T Yasukawa, R Young, AWE Jones, ... Nucleic acids research 45 (22), 12808-12815, 2017 | 49 | 2017 |
Interconverting conformations of slipped-DNA junctions formed by trinucleotide repeats affect repair outcome MM Slean, K Reddy, B Wu, K Nichol Edamura, M Kekis, FHT Nelissen, ... Biochemistry 52 (5), 773-785, 2013 | 42 | 2013 |
A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels K Reddy, JR Jenquin, OL McConnell, JD Cleary, JI Richardson, BS Pinto, ... Proceedings of the National Academy of Sciences 116 (42), 20991-21000, 2019 | 31 | 2019 |
ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy MT Handley, K Reddy, J Wills, E Rosser, A Kamath, M Halachev, ... PLoS Genetics 15 (3), e1007605, 2019 | 30 | 2019 |
Mitigating RNA toxicity in myotonic dystrophy using small molecules K Reddy, JR Jenquin, JD Cleary, JA Berglund International Journal of Molecular Sciences 20 (16), 4017, 2019 | 26 | 2019 |
CCG• CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity BA Perez, HK Shorrock, M Banez‐Coronel, T Zu, LEL Romano, ... EMBO Molecular Medicine 13 (11), e14095, 2021 | 22 | 2021 |
RAN translation: Fragile X in the running K Reddy, CE Pearson Neuron 78 (3), 405-408, 2013 | 14 | 2013 |
Disease-associated inosine misincorporation into RNA hinders translation JH Schroader, LA Jones, R Meng, HK Shorrock, JI Richardson, ... Nucleic Acids Research 50 (16), 9306-9318, 2022 | 13 | 2022 |
Inosine triphosphate pyrophosphatase: A guardian of the cellular nucleotide pool and potential mediator of RNA function JH Schroader, MT Handley, K Reddy Wiley Interdisciplinary Reviews: RNA 14 (5), e1790, 2023 | 4 | 2023 |
The unusual structural properties and potential biological relevance of switchback DNA BR Madhanagopal, H Talbot, A Rodriguez, JM Louis, H Zeghal, ... Nature Communications 15 (1), 6636, 2024 | 3 | 2024 |
CAG repeat-selective compounds reduce abundance of expanded CAG RNAs in patient cell and murine models of SCAs HK Shorrock, A Aliyeva, JA Frias, VA DeMeo, CD Lennon, CC DeMeo, ... bioRxiv, 2024.08. 17.608349, 2024 | 2 | 2024 |
Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy SK Mishra, SM Hicks, JA Frias, S Vangaveti, M Nakamori, JD Cleary, ... bioRxiv, 2023 | 2 | 2023 |
Drug screen tugs at common thread for repeat disorders K Reddy, JD Cleary, JA Berglund Trends in Pharmacological Sciences 41 (2), 71-73, 2020 | 2 | 2020 |
Expression levels of core spliceosomal proteins modulate the MBNL-mediated spliceopathy in DM1 JM Louis, JA Frias, JH Schroader, LA Jones, EE Davey, CD Lennon, ... Human Molecular Genetics 33 (21), 1873-1886, 2024 | 1 | 2024 |