Alleviating cancer drug toxicity by inhibiting a bacterial enzyme BD Wallace, H Wang, KT Lane, JE Scott, J Orans, JS Koo, M Venkatesh, ... Science 330 (6005), 831-835, 2010 | 1001 | 2010 |
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4 M Venkatesh, S Mukherjee, H Wang, H Li, K Sun, AP Benechet, Z Qiu, ... Immunity 41 (2), 296-310, 2014 | 837 | 2014 |
Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity BD Wallace, AB Roberts, RM Pollet, JD Ingle, KA Biernat, SJ Pellock, ... Chemistry & biology 22 (9), 1238-1249, 2015 | 251 | 2015 |
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor H Wang, H Li, LB Moore, MDL Johnson, JM Maglich, B Goodwin, ... Molecular endocrinology 22 (4), 838-857, 2008 | 148 | 2008 |
Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity AB Roberts, BD Wallace, MK Venkatesh, S Mani, MR Redinbo Molecular Pharmacology 84 (2), 208-217, 2013 | 144 | 2013 |
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice H Wang, M Venkatesh, H Li, R Goetz, S Mukherjee, A Biswas, L Zhu, ... The Journal of clinical investigation 121 (8), 3220-3232, 2011 | 142 | 2011 |
Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer D Gupta, M Venkatesh, H Wang, S Kim, M Sinz, GL Goldberg, K Whitney, ... Clinical Cancer Research 14 (17), 5332-5340, 2008 | 128 | 2008 |
Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis W Dou, S Mukherjee, H Li, M Venkatesh, H Wang, S Kortagere, A Peleg, ... PloS one 7 (7), e36075, 2012 | 95 | 2012 |
In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation M Venkatesh, H Wang, J Cayer, M Leroux, D Salvail, B Das, JE Wrobel, ... Molecular pharmacology 80 (1), 124-135, 2011 | 60 | 2011 |
Design, synthesis and biological evaluation of 2H-benzo [b][1, 4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics BC Das, AV Madhukumar, J Anguiano, S Mani Bioorganic & medicinal chemistry letters 19 (15), 4204-4206, 2009 | 52 | 2009 |
Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database S Kortagere, MD Krasowski, EJ Reschly, M Venkatesh, S Mani, S Ekins Environmental health perspectives 118 (10), 1412-1417, 2010 | 46 | 2010 |
Pregnane X receptor regulates pathogen-induced inflammation and host defense against an intracellular bacterial infection through toll-like receptor 4 Z Qiu, JL Cervantes, BB Cicek, S Mukherjee, M Venkatesh, LA Maher, ... Scientific reports 6 (1), 31936, 2016 | 43 | 2016 |
Synthesis of novel ketoconazole derivatives as inhibitors of the human pregnane X receptor (PXR; NR1I2; also termed SXR, PAR) BC Das, AV Madhukumar, J Anguiano, S Kim, M Sinz, TA Zvyaga, ... Bioorganic & medicinal chemistry letters 18 (14), 3974-3977, 2008 | 36 | 2008 |
Novel Yeast-Based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR H Li, MR Redinbo, M Venkatesh, S Ekins, A Chaudhry, N Bloch, ... Journal of Biological Chemistry, 2013 | 32 | 2013 |
Novel non-enzymatic toxic peptide of Daboia russelii (Eastern region) venom renders commercial polyvalent antivenom ineffective AV Kumar, TV Gowda Toxicon 47 (4), 398-408, 2006 | 21 | 2006 |
Purification, Characterization, and Chemical Modification of Neurotoxic Peptide from Daboia russelii Snake Venom of India M Venkatesh, N Prasad, T Sing, V Gowda Journal of Biochemical and Molecular Toxicology 27 (6), 295-304, 2013 | 17 | 2013 |
Synergistically acting PLA2: Peptide hemorrhagic complex from Daboia russelii venom M Venkatesh, V Gowda Toxicon 73, 111-120, 2013 | 16 | 2013 |
Development and characterization of a genetic mouse model of KRAS mutated colorectal cancer R Maitra, T Thavornwatanayong, MK Venkatesh, C Chandy, D Vachss, ... International journal of molecular sciences 20 (22), 5677, 2019 | 8 | 2019 |
Reovirus oncolysis-Role of cyclin-dependent kinase inhibitor 1 R Maitra, T Augustine, MK Venkatesh, S Goel Cancer Cell Microenviron 2, e750, 2015 | 1 | 2015 |
Development of a mouse model of KRAS mutated colorectal cancer tumorigenesis R Maitra, MK Venkatesh, TA Augustine, C Chandy, Q Liu, S Goel Cancer Research 77 (13_Supplement), 2799-2799, 2017 | | 2017 |