Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host JD Maya, BK Cassels, P Iturriaga-Vásquez, J Ferreira, M Faúndez, ... Comparative Biochemistry and Physiology Part A: Molecular & Integrative …, 2007 | 507 | 2007 |
Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives JD Maya, S Bollo, LJ Nunez-Vergara, JA Squella, Y Repetto, A Morello, ... Biochemical Pharmacology 65 (6), 999-1006, 2003 | 240 | 2003 |
Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets L Otero, M Vieites, L Boiani, A Denicola, C Rigol, L Opazo, C Olea-Azar, ... Journal of medicinal chemistry 49 (11), 3322-3331, 2006 | 220 | 2006 |
Trypanosoma cruzi: activities of lapachol and α-and β-lapachone derivatives against epimastigote and trypomastigote forms C Salas, RA Tapia, K Ciudad, V Armstrong, M Orellana, U Kemmerling, ... Bioorganic & medicinal chemistry 16 (2), 668-674, 2008 | 141 | 2008 |
Effects of nifurtimox and benznidazole upon glutathione and trypanothione content in epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi. JD Maya, Y Repetto, M Agosín, JM Ojeda, R Tellez, C Gaule, A Morello | 131 | 1997 |
Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease C O. Salas, M Faúndez, A Morello, J Diego Maya, R A. Tapia Current medicinal chemistry 18 (1), 144-161, 2011 | 126 | 2011 |
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies A Gerpe, G Aguirre, L Boiani, H Cerecetto, M González, C Olea-Azar, ... Bioorganic & medicinal chemistry 14 (10), 3467-3480, 2006 | 122 | 2006 |
Buthionine Sulfoximine Increases the Toxicity of Nifurtimox and Benznidazole to Trypanosoma cruzi M Faundez, L Pino, P Letelier, C Ortiz, R López, C Seguel, J Ferreira, ... Antimicrobial agents and chemotherapy 49 (1), 126-130, 2005 | 122 | 2005 |
Chagas disease: Present status of pathogenic mechanisms and chemotherapy JD Maya, M Orellana, J Ferreira, U Kemmerling, R López-Muñoz, ... Biological research 43 (3), 323-331, 2010 | 115 | 2010 |
Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on cancer cell lines. Validation in vivo in singenic mice JA Jara, V Castro-Castillo, J Saavedra-Olavarría, L Peredo, M Pavanni, ... Journal of medicinal chemistry 57 (6), 2440-2454, 2014 | 112 | 2014 |
Platinum (II) metal complexes as potential anti-Trypanosoma cruzi agents M Vieites, L Otero, D Santos, J Toloza, R Figueroa, E Norambuena, ... Journal of inorganic biochemistry 102 (5-6), 1033-1043, 2008 | 104 | 2008 |
Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties S Vazquez-Rodriguez, R Figueroa-Guinez, MJ Matos, L Santana, ... MedChemComm 4 (6), 993-1000, 2013 | 100 | 2013 |
Platinum-based complexes of bioactive 3-(5-nitrofuryl) acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity M Vieites, L Otero, D Santos, C Olea-Azar, E Norambuena, G Aguirre, ... Journal of Inorganic Biochemistry 103 (3), 411-418, 2009 | 99 | 2009 |
Trypanosoma cruzi induces tissue disorganization and destruction of chorionic villi in an ex vivo infection model of human placenta J Duaso, G Rojo, G Cabrera, N Galanti, C Bosco, JD Maya, A Morello, ... Placenta 31 (8), 705-711, 2010 | 95 | 2010 |
2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities I Sieveking, P Thomas, JC Estévez, N Quiñones, MA Cuéllar, J Villena, ... Bioorganic & medicinal chemistry 22 (17), 4609-4620, 2014 | 89 | 2014 |
Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease C Genes, E Baquero, F Echeverri, JD Maya, O Triana Parasites & vectors 4, 1-8, 2011 | 88 | 2011 |
Potential mechanism of the anti-trypanosomal activity of organoruthenium complexes with bioactive thiosemicarbazones B Demoro, M Rossi, F Caruso, D Liebowitz, C Olea-Azar, U Kemmerling, ... Biological trace element research 153, 371-381, 2013 | 72 | 2013 |
Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR spectroscopic studies J Rodríguez, A Gerpe, G Aguirre, U Kemmerling, OE Piro, VJ Arán, ... European journal of medicinal chemistry 44 (4), 1545-1553, 2009 | 70 | 2009 |
Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives F Pérez-Cruz, S Serra, G Delogu, M Lapier, JD Maya, C Olea-Azar, ... Bioorganic & medicinal chemistry letters 22 (17), 5569-5573, 2012 | 67 | 2012 |
ESR Spin Trapping Studies of Free Radicals Generated from Nitrofuran Derivative Analogues of Nifurtimox by Electrochemical and Trypanosoma cruzi Reduction C Olea-Azar, C Rigol, F Mendizabal, A Morello, J Diego Maya, ... Free radical research 37 (9), 993-1001, 2003 | 63 | 2003 |