The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder GS Stewart, RS Maser, T Stankovic, DA Bressan, MI Kaplan, NGJ Jaspers, ... Cell 99 (6), 577-587, 1999 | 1254 | 1999 |
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage GS Stewart, S Panier, K Townsend, AK Al-Hakim, NK Kolas, ES Miller, ... Cell 136 (3), 420-434, 2009 | 882 | 2009 |
ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer T Stankovic, AMJ Kidd, A Sutcliffe, GM McGuire, P Robinson, P Weber, ... The American Journal of Human Genetics 62 (2), 334-345, 1998 | 449 | 1998 |
Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia T Stankovic, P Weber, G Stewart, T Bedenham, J Murray, PJ Byrd, ... The Lancet 353 (9146), 26-29, 1999 | 442 | 1999 |
Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia F Nadeu, J Delgado, C Royo, T Baumann, T Stankovic, M Pinyol, P Jares, ... Blood, The Journal of the American Society of Hematology 127 (17), 2122-2130, 2016 | 403 | 2016 |
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions M Zimmermann, O Murina, MAM Reijns, A Agathanggelou, R Challis, ... Nature 559 (7713), 285-289, 2018 | 383 | 2018 |
Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid … O Goodyear, A Agathanggelou, I Novitzky-Basso, S Siddique, ... Blood, The Journal of the American Society of Hematology 116 (11), 1908-1918, 2010 | 381 | 2010 |
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL B Austen, JE Powell, A Alvi, I Edwards, L Hooper, J Starczynski, ... Blood 106 (9), 3175-3182, 2005 | 354 | 2005 |
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo VJ Weston, CE Oldreive, A Skowronska, DG Oscier, G Pratt, MJS Dyer, ... Blood, The Journal of the American Society of Hematology 116 (22), 4578-4587, 2010 | 353 | 2010 |
Mutation Status of the Residual ATM Allele Is an Important Determinant of the Cellular Response to Chemotherapy and Survival in Patients With Chronic … B Austen, A Skowronska, C Baker, JE Powell, A Gardiner, D Oscier, ... Journal of Clinical Oncology 25 (34), 5448-5457, 2007 | 348 | 2007 |
p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative toTP53 mutation AR Pettitt, PD Sherrington, G Stewart, JC Cawley, AMR Taylor, ... Blood, The Journal of the American Society of Hematology 98 (3), 814-822, 2001 | 331 | 2001 |
Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers C Pepper, TT Lin, G Pratt, S Hewamana, P Brennan, L Hiller, R Hills, ... Blood, The Journal of the American Society of Hematology 112 (9), 3807-3817, 2008 | 316 | 2008 |
ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells M Kwok, N Davies, A Agathanggelou, E Smith, C Oldreive, E Petermann, ... Blood, The Journal of the American Society of Hematology 127 (5), 582-595, 2016 | 305 | 2016 |
PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ... Cancer research 73 (11), 3336-3346, 2013 | 300 | 2013 |
Mutations associated with variant phenotypes in ataxia-telangiectasia. CM McConville, T Stankovic, PJ Byrd, GM McGuire, QY Yao, GG Lennox, ... American journal of human genetics 59 (2), 320, 1996 | 230 | 1996 |
BOD1L is required to suppress deleterious resection of stressed replication forks MR Higgs, JJ Reynolds, A Winczura, AN Blackford, V Borel, ES Miller, ... Molecular cell 59 (3), 462-477, 2015 | 214 | 2015 |
Ataxia telangiectasia mutated–deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired … T Stankovic, GS Stewart, C Fegan, P Biggs, J Last, PJ Byrd, RD Keenan, ... Blood, The Journal of the American Society of Hematology 99 (1), 300-309, 2002 | 198 | 2002 |
Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. ND Lakin, P Weber, T Stankovic, ST Rottinghaus, AM Taylor, SP Jackson Oncogene 13 (12), 2707-2716, 1996 | 197 | 1996 |
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling GS Stewart, T Stankovic, PJ Byrd, T Wechsler, ES Miller, A Huissoon, ... Proceedings of the National Academy of Sciences 104 (43), 16910-16915, 2007 | 193 | 2007 |
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks G Balmus, D Pilger, J Coates, M Demir, M Sczaniecka-Clift, AC Barros, ... Nature communications 10 (1), 87, 2019 | 178 | 2019 |