Thomas Clausen
Thomas Clausen
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SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2
TM Clausen, DR Sandoval, CB Spliid, J Pihl, HR Perrett, CD Painter, ...
Cell 183 (4), 1043-1057. e15, 2020
Targeting human cancer by a glycosaminoglycan binding malaria protein
A Salanti, TM Clausen, MØ Agerbæk, N Al Nakouzi, M Dahlbäck, HZ Oo, ...
Cancer cell 28 (4), 500-514, 2015
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria
TM Clausen, S Christoffersen, M Dahlbäck, AE Langkilde, KE Jensen, ...
Journal of Biological Chemistry 287 (28), 23332-23345, 2012
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
S Yuan, X Yin, X Meng, JFW Chan, ZW Ye, L Riva, L Pache, CCY Chan, ...
Nature 593 (7859), 418-423, 2021
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
MØ Agerbæk, SR Bang-Christensen, MH Yang, TM Clausen, MA Pereira, ...
Nature communications 9 (1), 3279, 2018
The GAGOme: a cell-based library of displayed glycosaminoglycans
YH Chen, Y Narimatsu, TM Clausen, C Gomes, R Karlsson, C Steentoft, ...
Nature methods 15 (11), 881-888, 2018
The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains
M Dahlbäck, LM Jørgensen, MA Nielsen, TM Clausen, SB Ditlev, ...
Journal of Biological Chemistry 286 (18), 15908-15917, 2011
Virus-like particle display of HER2 induces potent anti-cancer responses
A Palladini, S Thrane, CM Janitzek, J Pihl, SB Clemmensen, ...
Oncoimmunology 7 (3), e1408749, 2018
A High-Throughput O-Glycopeptide Discovery Platform for Seromic Profiling
O Blixt, E Cló, AS Nudelman, KK Sørensen, T Clausen, HH Wandall, ...
Journal of proteome research 9 (10), 5250-5261, 2010
Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1
M Ayres Pereira, T Mandel Clausen, C Pehrson, Y Mao, M Resende, ...
PLoS pathogens 12 (8), e1005831, 2016
The role of proteoglycans in cancer metastasis and circulating tumor cell analysis
TD Ahrens, SR Bang-Christensen, AM Jørgensen, C Løppke, CB Spliid, ...
Frontiers in cell and developmental biology 8, 749, 2020
Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility
TM Clausen, MA Pereira, N Al Nakouzi, HZ Oo, MØ Agerbæk, S Lee, ...
Molecular Cancer Research 14 (12), 1288-1299, 2016
Capture and detection of circulating glioma cells using the recombinant VAR2CSA malaria protein
SR Bang-Christensen, RS Pedersen, MA Pereira, TM Clausen, C Løppke, ...
Cells 8 (9), 998, 2019
An oncofetal glycosaminoglycan modification provides therapeutic access to cisplatin-resistant bladder cancer
R Seiler, HZ Oo, D Tortora, TM Clausen, CK Wang, G Kumar, MA Pereira, ...
European urology 72 (1), 142-150, 2017
Spike-heparan sulfate interactions in SARS-CoV-2 infection
FL Kearns, DR Sandoval, L Casalino, TM Clausen, MA Rosenfeld, ...
Current Opinion in Structural Biology 76, 102439, 2022
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
SB Biering, FT Gomes de Sousa, LV Tjang, F Pahmeier, C Zhu, R Ruan, ...
Nature communications 13 (1), 7630, 2022
Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity
C Martino, BP Kellman, DR Sandoval, TM Clausen, CA Marotz, SJ Song, ...
BioRxiv, 2020.08. 17.238444, 2020
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
R Karlsson, P Chopra, A Joshi, Z Yang, SY Vakhrushev, TM Clausen, ...
Science advances 7 (52), eabl6026, 2021
Noninvasive detection of any-stage cancer using free glycosaminoglycans
S Bratulic, A Limeta, S Dabestani, H Birgisson, G Enblad, K Stålberg, ...
Proceedings of the National Academy of Sciences 119 (50), e2115328119, 2022
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
K Wang, R Dagil, T Lavstsen, SK Misra, CB Spliid, Y Wang, T Gustavsson, ...
Nature Communications 12 (1), 2956, 2021
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